معرفی
Dr. Mehmet Sofuoglu is a Professor of Psychiatry at Yale School of Medicine and Director of the VA New England Mental Illness Research, Education, and Clinical Center (MIRECC). He holds appointments in multiple departments and research centers, including the Cancer Prevention and Control Center, the Center for Nicotine and Tobacco Use Research (CENTURY), and the Stress & Addiction Clinical Research Program. His work focuses on developing novel treatments for substance use disorders, with a particular emphasis on nicotine, opioids, and comorbid pain conditions. Dr. Sofuoglu also leads the Yale Tobacco Center of Regulatory Science, which examines the impact of nicotine and flavors on tobacco product appeal and abuse potential.
Education
- MD: Hacettepe University Faculty of Medicine (1986)
- PhD: University of Minnesota (1991)
Research Interests
Dr. Sofuoglu’s research integrates clinical trials and human laboratory studies to explore treatments for addiction. Key areas include:
- Intravenous nicotine self-administration models to study rewarding/aversive effects
- Impact of cigarette flavors (e.g., menthol) on smoking behavior
- Cognitive enhancers (e.g., donepezil) for addiction treatment
- Progesterone’s role in relapse prevention for women with substance use disorders
- Comorbid pain and opioid use disorder management
Recent Articles & Trends
His 2025 work highlights nicotine e-cigarette efficacy, menthol’s effects on nicotine response, and the bidirectional relationship between tobacco use and pain. 2024 research emphasized opioid crisis challenges, racial disparities in smoking outcomes, and psychedelic therapies for pain/opioid comorbidities. A notable 2023 $20M federal grant supports tobacco regulatory science efforts.
Grants & Teams
He leads federally funded studies on pain-addiction interactions and tobacco product regulation. Collaborations include the Stress & Addiction Clinical Research Program and interdisciplinary teams addressing opioid crisis complexities.
