معرفی
Meghan Moran, PhD is an Assistant Professor in the Department of Anatomy & Cell Biology at Rush Medical College, Rush University. Her research focuses on the molecular interactions between the gut, gut microbiome and bone as a mechanistic pathway to delaying or mitigating arthroplasty failure due to peri-implant particle-induced osteolysis. She serves as Manager for MicroCT and Hard Tissue Histology Cores at Rush University Medical Center.
- PhD, Kent State University/Northeast Ohio Medical University
Dr. Moran is a bone biologist whose research centers on the gut-bone axis, particularly investigating how the gut microbiome influences bone regeneration and implant fixation in joint arthroplasty. Her work explores the symbiotic relationship between gut microorganisms and musculoskeletal system function, with specific focus on how microbiota impacts osteoarthritis, rheumatoid arthritis, fracture healing and osteolysis. Her laboratory uses preclinical and translational models to investigate the cross-talk between the gut and the implant microenvironment to enhance bone regeneration and implant survivorship.
Analysis of Dr. Moran's publication record reveals a strong focus on bone regeneration mechanisms, particularly intramembranous ossification, and the relationship between gut physiology and orthopedic implant outcomes. Her recent work has increasingly emphasized the gut microbiome's role in peri-implant osteolysis, with multiple studies examining how microbial communities influence inflammatory responses to orthopedic implants. Her research employs diverse methodologies including micro-computed tomography, mechanical testing, histomorphometry, and 16S amplicon sequencing to investigate bone-implant interactions.
Dr. Moran has been involved as Co-Investigator on several significant NIH-funded projects including: 1R01 AR079179 "Systems Genetics of Bone Regeneration," 1R21 HD102026 "Establishing a New Model of Bone Health in Formerly Premature Individuals," and 1R01 AR066562 "Detection and treatment of peri-implant osteolysis." Her laboratory, part of the Department of Anatomy & Cell Biology at Rush University Medical Center, utilizes various advanced techniques including micro-computed tomography, mechanical testing, dynamic histomorphometry, immunohistochemical staining, and bioinformatics to investigate bone-implant interactions and gut-bone axis mechanisms.
