Maurizio Bocchetta

Maurizio Bocchetta is an Associate Professor in Cancer Biology at Loyola University Chicago. His research focuses on understanding molecular mechanisms of lung adenocarcinoma, particularly the role of OTUD6B deubiquitinase in regulating MYC oncogene activity. His work explores γ-secretase inhibitors' effects beyond Notch signaling pathways, aiming to identify novel therapeutic strategies for lung cancer.

Education:

• BA/MS in Human Physiology, University of Rome 'La Sapienza', Italy
• PhD in Human Molecular Biology, University of Rome 'La Sapienza', Italy
• Postdoctoral Fellowship at University of Illinois at Chicago

Research Interests:

• OTUD6B regulation of oncogenic proteins
• Post-translational modification networks in cancer
• Lung adenocarcinoma biology and therapeutics
• Notch signaling pathway in tumor progression
• SV40 virus oncogenic mechanisms

Publications Overview: Dr. Bocchetta has published extensively on γ-secretase inhibitors' mechanisms, OTUD6B's role in cancer, and Notch signaling's impact in lung and breast cancers. His recent work explores potassium channel activation as a therapeutic angle for c-Myc degradation in lung tumors.

Laboratory Work: Leads a lab investigating tumor microenvironment responses, hypoxia adaptation, and translational control in cancer cells. Active in developing multimodal therapies targeting lung carcinoma-specific vulnerabilities.