Matthias Stadtfeld

Matthias Stadtfeld is an Associate Professor at Weill Cornell Medicine, affiliated with the Graduate School of Medical Sciences and the Department of Medicine. His laboratory is dedicated to understanding epigenetic mechanisms that govern cell identity and function in mammals, using pluripotent stem cells and cellular reprogramming as central models.

His research focuses on the interplay between transcriptional regulation, chromatin remodeling, and metabolic changes during cellular reprogramming. Key areas include the maintenance of epigenetic integrity, dysregulation in disease, and the role of genomic imprinting in development and cancer. The lab employs cutting-edge techniques such as CRISPR screening, epigenome profiling, and transgenic mouse models.

The publications reflect a strong emphasis on epigenetic stability, loss-of-imprinting, and the functional analysis of chromatin regulators in both mouse and human systems, contributing to broader fields like regenerative medicine and developmental disorders.

• Supported by major research agencies and foundations
• Actively mentoring graduate students, including rotation trainees
• Integrates genetic engineering with functional genomics to dissect regulatory networks

Scientific Awards:

• No specific awards listed in the provided text.

Dr. Stadtfeld advises graduate students and is involved in training the next generation of scientists through the BCMB and Cell & Developmental Biology programs. His lab fosters a collaborative environment, welcoming new trainees and promoting outreach via social media and academic engagement. The Stadtfeld Lab investigates both known regulators of epigenetic stability and performs forward genetic screens to discover novel factors influencing epigenetic fidelity.