معرفی
Dr. Matthias Bütikofer is a Researcher at the Chair of Physical Chemistry at ETH Zurich, affiliated with the Institute of Molecular Physical Sciences (IMPS). His work focuses on advancing NMR-based methodologies for drug discovery, particularly targeting oncogenic proteins like KRAS and viral proteases such as the SARS-CoV-2 Main Protease (Mpro). He develops cutting-edge techniques like hyperpolarization and benchtop NMR platforms to enhance sensitivity and accessibility in structural biology and drug screening.
Research interests include fragment-based drug design, photoinduced hyperpolarization for rapid ligand affinity determination, and automated NMR platforms for low-concentration sample analysis. His contributions span structural elucidation of protein-ligand complexes using NMR2 technology, as well as identifying natural products to combat viral pathogens. Recent efforts have emphasized scaling NMR applications for widespread use in pharmaceutical research.
Key projects include structural studies of KRAS G12V mutations in drug-bound states, high-throughput screening of SARS-CoV-2 proteases, and leveraging in-cell NMR for intracellular protein analysis. His work bridges biophysical chemistry with translational medicine, aiming to accelerate therapeutic development through advanced spectroscopic tools.
