Gyula Pálfy

Dr. Gyula Pálfy is a Researcher at the Institute of Biochemistry, ETH Zurich, specializing in biomolecular NMR spectroscopy. He operates within the Professorship for Biomolecular NMR, focusing on structural characterization of disease-relevant proteins with applications in virology and oncology.

His research expertise centers on:

• Structural analysis of SARS-CoV-2 accessory proteins (ORF6, ORF7b) and their membrane interactions
• Dynamics of oncogenic KRAS mutants (G12C, G12D, G12V) and covalent drug targeting
• p53 tumor suppressor interactions with metastasis-associated proteins
• Development of NMR-driven protocols for mapping protein binding sites
• Thermal stability studies of enzymes like lactase

Recent publications reveal a strong emphasis on covalent drug discovery against challenging targets like KRAS, utilizing photoreactive fragments and dynamic undocking protocols. His work bridges structural biology with therapeutic development, particularly in cancer and viral pathogenesis, while advancing NMR methodologies for studying dynamic protein states.

Dr. Pálfy actively contributes to the RASopathy consortium and collaborates on interdisciplinary projects at ETH Zurich's Institute of Biochemistry, where he maintains laboratory operations for NMR-based structural studies.