معرفی
Dr. Matthias Baud is an Associate Professor in Medicinal Chemistry and Chemical Biology at the University of Southampton's School of Chemistry. He leads multidisciplinary research combining synthetic organic chemistry, biophysical techniques (DSF/DSC, ITC, NMR), and computational methods to develop protein-modulating agents for human health applications, particularly in cancer and rare diseases. His work focuses on small molecule design to stabilize or activate proteins, with clinical translation for conditions like Multiple Sulfatase Deficiency and p53 mutant-driven cancers.
Education: BSc (Université de Besançon, 2006), MSc (EPFL, 2008), PhD (Imperial College London, 2011 under Prof. Matthew Fuchter). Career highlights include an MRC Career Development Fellowship (2013-2016) and promotion to Associate Professor at Southampton in 2022. He has supervised numerous PhD students in medicinal chemistry and chemical biology.
Key research areas: protein reactivation, targeted covalent inhibitors, PROTAC linkers, and small molecule therapies for orphan diseases. Awards include the 2016 Roger Griffin Prize for Cancer Drug Discovery. Active projects include therapeutic agent optimization for Multiple Sulfatase Deficiency and vision loss in albinism, funded by MSD Action Foundation and EPSRC.
Teaching responsibilities include Chemical Biology, Medicinal Chemistry, and laboratory skills modules. His lab collaborates with biological teams to translate chemical innovations into clinical applications, emphasizing interdisciplinary approaches.
