معرفی
Dr. Matthew Tredwell serves as Senior Research Fellow in the School of Medicine and Senior Lecturer in Medicinal Chemistry in the School of Chemistry at Cardiff University, where he has held academic positions since 2019. His research program bridges synthetic organic chemistry with radiochemistry, with a focus on developing novel methods for PET imaging applications.
Dr. Tredwell's research interests center on organofluorine chemistry and fluorine-18 radiochemistry. His group develops innovative synthetic methodologies including transition-metal catalyzed synthesis of C-CF3 stereogenic centers, electrochemical fluorination techniques, and novel fluorinated motifs. His radiochemistry work focuses on the synthesis of 18F-perfluorinated motifs, radiotracer development, and clinical translation of radiochemical technologies for PET imaging applications.
Analysis of his recent publications reveals a strong emphasis on expanding the radiochemical space for fluorine-18 labeling, with particular focus on developing methods for difluoromethyl and trifluoromethyl group incorporation into biologically relevant molecules. His work spans fundamental synthetic methodology development to practical applications in radiopharmaceutical production, with increasing emphasis on clinical translation in recent years.
Dr. Tredwell maintains an active research program with consistent high-impact publications in top chemistry journals including Nature, Journal of the American Chemical Society, and Angewandte Chemie. His work demonstrates a clear progression from fundamental organofluorine chemistry toward increasingly applied radiochemical methods with direct relevance to medical imaging.
As an educator, Dr. Tredwell supervises postgraduate students in radiochemistry, organic chemistry, radiotracer design, and medicinal chemistry. His Tredwell Group operates fully equipped laboratories capable of performing both synthetic chemistry and radiochemistry in-house, providing students with comprehensive training in both traditional and radiochemical synthesis.
