Matthew Stachler

Matthew Stachler is a Physician Scientist at the University of California San Francisco (UCSF), where he focuses on Molecular Pathology and Personalized Medicine in cancer diagnostics and treatment. His research explores the progression of Barrett’s Esophagus and Gastroesophageal Cancers using advanced genomics, proteomics, and digital imaging technologies.

Stachler’s work centers on understanding the genomic instability, molecular biomarkers, and immune microenvironment in upper gastrointestinal tract cancers, particularly Barrett’s Esophagus and its transformation into Esophageal Adenocarcinoma. He aims to develop novel screening strategies, biomarkers, and early interventions to improve patient outcomes.

His recent publications highlight TP53 mutations, chromosomal instability, and multi-omics approaches to study cancer progression. Stachler is a Principal Investigator on NIH grants focused on Barrett’s Esophagus risk stratification and genomic consequences in cancer development.

Current research projects include collaborations on digital spatial profiling, phosphoproteomic analysis, and functional studies to model cancer progression. His work bridges clinical pathology with translational research, emphasizing the importance of integrating molecular data into clinical practice.