Matthew R. Redinbo

Matthew R. Redinbo is a Professor at the University of North Carolina at Chapel Hill School of Medicine, holding the William R. Kenan Distinguished Professor chair in the Department of Chemistry. His research bridges structural biology, microbiology, and drug development to address human health challenges.

Research Focus:
• Molecular basis of human disease: Explores mechanisms of drug metabolism, nuclear receptors, and antibiotic resistance
• Gut microbiome: Develops activity-based probe-enabled proteomics pipelines for enzyme quantification in human feces
• Therapeutics discovery: Uses structural and chemical biology to design enzyme inhibitors

Key Techniques:
• Protein crystallography
• Pharmacokinetic (PK) studies
• Next-gen "omics" technologies (microbial sequencing, metabolomics)

Scientific Awards:

• Pilot and Feasibility Award (2008), Center for Gastrointestinal Biology and Disease

Article Trends:
Recent work emphasizes gut microbiome dynamics (bile acid metabolism, estrobolome), host-microbe interactions (PXR/TLR4 signaling), and structure-guided drug design (CHD1 antagonists, uremic toxin mitigation).

Collaborations:
Works with researchers across microbiology, pharmacology, and clinical medicine (Azcarate, Bhatt, Fodor, Gulati, Rawls, Sartor, Theriot). Leads projects integrating basic science with translational applications in murine models.