معرفی
Matthew D. Marsden is an Associate Professor in the Department of Microbiology & Molecular Genetics and the Division of Infectious Diseases at the University of California, Irvine School of Medicine. His research focuses on HIV pathogenesis, antiretroviral therapies, and strategies to eliminate latent viral reservoirs. He has made significant contributions to understanding the role of integrase inhibitors in post-exposure prophylaxis and the mechanisms underlying HIV latency. His work employs advanced models such as humanized mice and investigates novel therapies like CAR-T cells and latency-reversing agents.
Research Interests: Marsden’s studies prioritize HIV latency mechanisms, integrase inhibitor efficacy, and translational approaches to cure HIV. He explores the interplay between viral genetics, immune responses, and drug delivery systems to combat persistent infections.
Notable Contributions: His 2012 study demonstrated raltegravir’s extended efficacy window in PEP, and his 2015 work revealed HIV’s disruption of type I interferon pathways in T cells. Recent focus includes optimizing PKC modulators and CAR-T cell therapies to target latent reservoirs. His research bridges basic science and clinical applications, advocating for combination strategies in HIV cure efforts.
Grants & Funding: Supported by NIH grants (e.g., R01 AI070010), his work leverages interdisciplinary collaborations to advance HIV cure research. He also contributes to mentoring the next generation of virologists and immunologists through graduate and postdoctoral training programs.
