Martin Margittai

Martin Margittai is a Professor in the Department of Chemistry & Biochemistry at the University of Denver's College of Natural Sciences and Mathematics. His research focuses on protein aggregation mechanisms in neurodegenerative diseases, particularly Alzheimer's disease. He holds a Ph.D. in Biochemistry from Freie Universität Berlin (2001), an MS (1997), and a BS (1995) from the same institution.

• Ph.D., Biochemistry, Freie Universität Berlin, 2001
• MS, Biochemistry, Freie Universität Berlin, 1997
• BS, Biochemistry, Freie Universität Berlin, 1995

His research interests include the structural and dynamic aspects of tau protein aggregation, molecular mechanisms of neurodegenerative diseases, and the application of biophysical techniques such as Raman spectroscopy and electron paramagnetic resonance (EPR). He studies how tau fibrils form, interact with cellular components, and propagate pathology. Recent work explores the role of RNA binding, redox regulation, and extracellular vesicles in disease progression.

His publications highlight advancements in understanding tau conformational variants, fibril stability, and cross-seeding barriers between tau isoforms. These studies contribute to identifying biomarkers and therapeutic targets for Alzheimer's and related disorders.

Margittai is affiliated with the American Chemical Society and the American Society for Biochemistry and Molecular Biology. His teaching spans undergraduate and graduate courses in biochemistry and chemistry.