Markus T. Bohnsack

Prof. Dr. Markus T. Bohnsack is a Professor at the University Medical Center Göttingen, where he leads research on gene expression processes and RNA-protein complexes. His work is conducted through the Department of Molecular Biology, focusing on the intricate mechanisms that govern cellular function and identity.

Dr. Bohnsack's research interests span multiple interconnected areas of molecular biology:

• Biogenesis, dynamics, and regulation of ribonucleoprotein complexes (RNPs)
• Roles of RNA helicases in modulating RNA structure and function
• RNA modifications and their impact on gene expression
• Ribosome biogenesis pathways and associated enzymatic factors
• Cross-regulation between different gene expression processes

His laboratory employs a comprehensive toolkit including molecular biological, biochemical, and cell biological methods, along with transcriptome/proteome-wide approaches and interdisciplinary collaborations. Key methodologies include UV crosslinking and analysis of cDNA (CRAC) and mass spectrometry to discover protein-RNA and protein-protein interactions in vivo.

Dr. Bohnsack's work has significant implications for understanding disease mechanisms, as dysregulation of gene expression underlies many pathological conditions, and an increasing number of diseases have been linked to RNP malfunction.