Mark S Moehle

Mark S Moehle is an Assistant Professor in the Department of Pharmacology and Therapeutics at the University of Florida. His research focuses on understanding cellular and molecular mechanisms underlying neurological disorders such as Parkinson’s disease, dystonia, and Lewy Body Dementia. He leads the Moehle Laboratory, which employs pharmacological, electrophysiological, and behavioral techniques to investigate therapeutic strategies targeting muscarinic acetylcholine receptors (M4) and LRRK2 pathways. Moehle holds a PhD from Vanderbilt University and completed postdoctoral training at the University of Florida. He teaches courses including Pharmacotherapeutics I, Principles of Pharmacology, and Neuroscience seminars. Active grants include studies on α-synuclein pathology, cholinergic mechanisms in Lewy Body Dementia, and M4 receptor modulation in Parkinson’s disease. His work bridges basic science and translational research, aiming to develop novel treatments for movement disorders.

Education:

• PhD in Pharmacology (2015), Vanderbilt University
• Postdoctoral Fellowship (2015–2020), University of Florida
• Bachelor of Science (2010), Centenary College of Louisiana

Research Interests:

• Molecular mechanisms of α-synuclein aggregation and neurodegeneration
• Role of M4 muscarinic receptors in movement disorder pathogenesis
• Genetic and pharmacological modulation of LRRK2 signaling
• Development of antiparkinsonian and antidystonic therapies

Grants & Funding:

• Principal Investigator: NIH NINDS (Lewy Body Dementia research)
• Michael J. Fox Foundation (M5 modulators and α-synuclein studies)
• Co-Investigator: DYT1 dystonia modeling

Labs & Teams:

• Moehle Lab: Focused on circuit-level and biochemical analysis of movement disorder models
• Collaborations with neurology and pharmacology departments at UF