معرفی
Professor Johannes Attems is a leading academic at Newcastle University specializing in neurodegenerative diseases, particularly Alzheimer's disease, Parkinson's disease, and Lewy body dementias. His research focuses on neuropathological mechanisms, protein aggregation (tau, amyloid-β, α-synuclein), and the intersection of aging-related pathologies. He has contributed extensively to understanding cerebral amyloid angiopathy, mixed pathologies in dementia, and the role of genetic and environmental factors in neurodegeneration.
- Education: Formal qualifications not explicitly listed in text.
- Affiliations: Brains for Dementia Research Network, UK Medical Research Council Brain Banks.
His work bridges basic neuroscience with clinical diagnostics, including studies on biomarkers (e.g., platelet antioxidants, imaging correlates like DaTSCAN) and therapeutic targets (e.g., adrenergic receptors, montelukast). He collaborates internationally on large-scale neuropathological cohorts, examining how comorbidities (e.g., vascular disease, hearing loss) influence dementia progression.
Key contributions include advancing LATE-NC staging criteria, identifying α-synuclein pathology in monogenic disorders, and exploring mitochondrial dysfunction in Parkinson's disease. His research emphasizes the heterogeneity of neurodegenerative diseases and the need for precision medicine approaches.
