معرفی
Mark P. Brynildsen is a Professor in the Department of Chemical and Biological Engineering at Princeton University and an affiliated faculty member at the Omenn-Darling Bioengineering Institute and the Department of Molecular Biology. His research focuses on combating antibiotic resistance through systems and synthetic biology approaches, particularly addressing bacterial persistence and enhancing pathogen susceptibility to immune defenses.
Education:
- Ph.D., University of California, Los Angeles (2008)
- B.S., Rutgers University (2002)
Research Interests:
- Bacterial persistence mechanisms and their role in chronic infections
- Antivirulence therapies targeting host-pathogen interactions
- Synthetic biology tools for studying bacterial stress responses
- Metabolic regulation of persister formation
Recent Research Trends:
- Exploration of genetic and metabolic factors enabling antibiotic tolerance
- Development of novel strategies to disrupt bacterial defenses against immune antimicrobials
- Quantitative analysis of persister cell physiology using genome-wide approaches
Awards:
- NSF CAREER Award (2015-2020)
- Howard B. Wentz, Jr. Junior Faculty Award (2015)
- Multiple teaching and mentoring awards including the 2022 Graduate Mentoring Award
Advising & Grants:
- Advises PhD students including Allison Murawski, Darshan Sivaloganathan, and Katherine Sniezek
- Funded by NIH, NSF, and HHMI
Labs & Teams: Leads the Brynildsen Research Group, focusing on interdisciplinary approaches to antibiotic resistance.
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