Mark Chance

Mark Chance, PhD, is a Distinguished University Professor and holds professorships in the Departments of Nutrition, Genetics & Genome Sciences, and General Medical Sciences at Case Western Reserve University (CWRU). He directs the Center for Proteomics and Bioinformatics, the Center for Synchrotron Biosciences, and the Systems Biology Graduate Program. His research focuses on proteomics and systems biology in cancer and Alzheimer's Disease, with expertise in protein-protein interactions, structural mass spectrometry, and protein crystallography. Dr. Chance has published over 300 papers and leads federally funded projects, including roles in NIH grants and the Case Comprehensive Cancer Center. He is a Fellow of the AAAS and recipient of the Charles W. and Iona A. Mathias Chair in Cancer Research.

• Education: PhD in Biophysics from the University of Pennsylvania (1986)
• Affiliations: Member of the Case Comprehensive Cancer Center and Cleveland Center for Membrane & Structural Biology

Research Interests: Integrates proteomics, structural biology, and systems biology to study disease mechanisms. Key areas include Alzheimer's pathology, cancer signaling pathways, and protein dynamics using advanced techniques like hydroxyl radical footprinting and synchrotron-based methods. His work bridges basic science with translational applications, including startup NeoProteomics, Inc.

Funding & Awards: Over $50M in NIH grants, including leadership roles in P30 and R01 projects. Recognitions include the Naomi Kanof Award and AAAS Fellowship.