Marith Francke

Marith Francke is a Researcher in the Department of Internal Medicine at Erasmus MC, Erasmus University Rotterdam, specializing in pharmacokinetics and therapeutic drug monitoring of immunosuppressive agents for kidney transplant recipients. Her work focuses on optimizing tacrolimus therapy through population modeling and precision dosing approaches.

Her primary research interests include pharmacokinetics of immunosuppressants, therapeutic drug monitoring, transplant pharmacology, nephrology, and clinical pharmacology. She investigates CYP3A4/CYP3A5 polymorphisms, ethnic variability in drug response, alternative sampling matrices like dried blood spots, and pharmacokinetic changes in special populations including pregnant transplant recipients. Her work bridges laboratory research on intracellular drug concentrations with clinical applications for individualized dosing.

Analysis of her recent publications (2023-2025) reveals a cohesive research trajectory centered on tacrolimus optimization in kidney transplantation. Key themes include population pharmacokinetic modeling for dose individualization, exploration of genetic and physiological factors affecting drug exposure, and validation of novel monitoring techniques. Her research demonstrates strong international collaboration, particularly with Tunisian institutions, and consistently addresses critical gaps in transplant pharmacotherapy through methodological innovation and clinical validation.