Sebastiaan Sassen

Dr. Sebastiaan Sassen is a researcher in the Department of Pharmacy at Erasmus MC, specializing in clinical pharmacology with a focus on pharmacokinetics, pharmacodynamics, and therapeutic drug monitoring. His research integrates modeling and clinical data to optimize drug dosing, particularly in oncology, transplantation, and infectious diseases.

• Institution: Erasmus MC
• Department: Department of Pharmacy
• Role: Researcher

His research interests are deeply rooted in clinical pharmacology, with emphasis on population pharmacokinetic modeling, drug dosing optimization, and therapeutic monitoring. He investigates complex regimens involving intraperitoneal chemotherapy, immunomodulatory agents, and antimicrobial combinations, often applying quantitative methods to improve patient outcomes. His work spans transplant medicine (e.g., tacrolimus), oncology (e.g., docetaxel micelles), and neuroimmunology (e.g., IVIg in Guillain-Barré syndrome).

The most recent publications reveal a strong trend toward translational pharmacology, where preclinical models and clinical data are combined to inform dosing strategies. Key areas include antimicrobial synergy, nanoparticle drug delivery, and pharmacodynamic evaluation of second-line therapies. His collaborative work appears in high-impact journals such as Clinical Pharmacokinetics and Journal of Antimicrobial Chemotherapy.

Scientific Contributions:

• Developed dosing algorithms for tacrolimus in kidney transplant recipients
• Explored synergistic effects of polymyxin B and rifampicin in resistant infections
• Advanced understanding of intraperitoneal chemotherapy pharmacokinetics
• Modeled drug release from polymeric micelle systems
• Evaluated pharmacodynamics of repeated IVIg in autoimmune neuropathy

Dr. Sassen has contributed to the supervision of doctoral research, indicating an active role in academic mentoring. While specific grant details are not listed, his involvement in multicenter, high-impact studies suggests participation in funded research projects. He collaborates extensively with experts in pharmacy, oncology, nephrology, and infectious diseases.

His work is embedded in a network focused on improving drug therapy through modeling and clinical application. Though no formal lab name is mentioned, his research aligns with clinical pharmacology and translational pharmaceutics groups at Erasmus MC.