Marianne Müller

Marianne Müller is a Professor for Psychiatry and Psychotherapy at the University Medical Center of Johannes Gutenberg University Mainz, leading a research group focused on resilience mechanisms. Her interdisciplinary team integrates human medicine, natural sciences, and translational research to address fundamental questions in stress resilience.

Her research centers on resilience to stressful life events, with two primary pillars: (1) developing animal models for stress/resilience and (2) elucidating neurobiological mechanisms of resilience-promoting interventions. Key projects include characterizing resilience in mouse models, stress inoculation paradigms, DRR1 protein dynamics, ketamine's molecular actions, and dynamic system analysis tools.

The group's publication trends reveal strong emphasis on translational neuroscience (71% of articles), with subfields spanning rapid-acting antidepressants, glial cell biology, and stress-induced metabolic-cognitive interactions. Methodologically, they prioritize proteomics, behavioral phenotyping, and molecular validation in animal models.

Müller's leadership includes managing a 6-member research team and securing funding from major sources like DFG and Boehringer Ingelheim Stiftung. Her collaborative network spans Goethe-Universität Frankfurt, Max-Planck-Institut für Psychiatrie, Stanford University, and Emory University.

The group operates within the Department of Psychiatry and Psychotherapy, leveraging the University Medical Center's infrastructure for translational work. Current initiatives focus on instrument development for dynamic system analysis (IDSAIR project) and pharmacological modeling of resilience factors.