معرفی
Maria Shchepinova is a Lecturer in the Department of Chemistry at the University of Bath, where she leads the GPCR Chemical Biology and Proteomics Group. She is actively involved in research and accepts doctoral students for PhD projects in chemical biology, molecular biology, and proteomics.
- PhD, Chemical Biology, University of Glasgow (2017)
- MSci, Bioorganic Chemistry, Lomonosov Moscow State University (2012)
Her research integrates chemistry, molecular biology, and proteomics to develop high-precision chemical biology approaches for studying dynamic protein interactions, particularly focusing on G protein-coupled receptors (GPCRs). Her work aims to understand the molecular mechanisms of disease and promote new drug discovery, especially in metabolic disorders like type 2 diabetes. Key areas include APEX2 proximity proteomics for mapping GPCR interactomes, investigating the impact of lipid peroxidation on GPCR function, and developing light-responsive and antibody-conjugated chemical tools.
The most recent publications show a strong trend in spatiotemporal mapping of GPCR interactomes, targeted protein degradation (e.g., PROTACs), and the development of novel chemical probes for redox biology and receptor signaling. These works span disciplines such as chemical biology, proteomics, pharmacology, and drug discovery, with a consistent focus on innovative methodologies to interrogate protein function in live cells.
She has no listed scientific awards in the provided text.
Maria Shchepinova has held research positions at Imperial College London (2016–2024) and is now an independent academic at the University of Bath. She collaborates with leading scientists such as Prof. Ed Tate and Prof. Aylin Hanyaloglu. Her lab is multidisciplinary, integrating chemical synthesis, cell signaling assays, confocal microscopy, and quantitative proteomics. She is actively seeking collaborations and new PhD students.
Her research group is centered on three pillars: chemistry, molecular biology, and proteomics. The team develops and applies cutting-edge technologies such as APEX2 proximity proteomics and chemogenetic tools to study GPCR signaling in health and disease, particularly under conditions of oxidative stress and lipid peroxidation.
