Maria J. C. Machado

Maria J. C. Machado is a researcher at the Tumour and Vascular Biology Laboratories, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, UK. Her work focuses on molecular mechanisms of vascular revascularization in peripheral ischemia models.

Research Interests: Investigates interactions between

• Notch signaling
• Nitric oxide pathways
• Angiopoietin-VEGF dynamics

in microvascular repair processes.

Key Findings: Demonstrates through mouse models that Dll4-Notch activation can paradoxically impair functional revascularization despite increasing vascular densities, highlighting critical temporal balances in growth factor signaling for effective blood flow recovery.