معرفی
Kim Dora is a Professor of Microvascular Pharmacology at the University of Oxford, affiliated with Worcester College. Her research focuses on understanding the mechanisms controlling microvascular tone and function, particularly in coronary and mesenteric arteries. She leads the Dora Group, which uses electrophysiological and live-cell imaging techniques to study endothelial signaling, ion channel activity, and vascular responses to pathophysiological conditions such as hypertension and diabetes.
Key research interests include endothelial hyperpolarization (EDH), myoendothelial gap junction signaling, and the role of endothelial-derived factors like nitric oxide and endothelin-1 in vascular health and disease. Her work has revealed novel pathways linking endothelial cell activity to smooth muscle tone regulation, with implications for therapies targeting cardiovascular disorders.
Dr. Dora holds a British Heart Foundation Senior Basic Science Research Fellowship and collaborates with institutions globally. Recent publications highlight discoveries in vasospasm mechanisms, SGLT2 inhibitor effects, and the role of phospholemman in blood pressure regulation. She advises DPhil student Lillian Wallis and oversees a multidisciplinary team investigating human coronary microvascular dysfunction and arteriolar signaling pathways.
- Research Themes: Cardiovascular Pharmacology, Microvascular Physiology, Vascular Signaling
- Lab Members: Prof. Christopher J. Garland (Vascular Pharmacology), Dr. Elizabeth Forrester (Postdoctoral Researcher), Dr. JinHeng Lin (Postdoctoral Researcher), Lauren Phillips (Postdoctoral Researcher), Toby Brown (Fellow in Medicine), Lillian Wallis (DPhil Student)
Her work integrates in vivo and ex vivo models, including human coronary arterioles, to bridge basic science and clinical applications. Current projects explore the impact of metabolic disorders on microvascular function and the therapeutic potential of targeting endothelial signaling pathways.
