معرفی
Marcus Wilhelmsson is a Professor of Chemistry and Biochemistry at Chalmers University of Technology in Gothenburg, Sweden, where he leads a research group focused on developing fluorescent base analogs for DNA and RNA. His work bridges chemistry, biophysics, and molecular biology to create tools for studying nucleic acid structure, dynamics, and protein interactions.
His research interests center on nucleic acid chemistry and the development of fluorescent probes for biological applications. Wilhelmsson's group designs novel fluorescent base analogs that enable researchers to study DNA and RNA structure, dynamics, and interactions with proteins without significantly perturbing the native biomolecules. His work spans chemical synthesis, photophysical characterization, and biological applications of these probes.
Analysis of Wilhelmsson's recent publications (2020-2025) reveals a strong focus on developing and applying fluorescent nucleoside analogs for studying RNA structure and dynamics, with particular emphasis on viral RNA (including SARS-CoV-2), microRNA, and RNA-based therapeutics. His research integrates biophysical techniques like optical tweezers, force spectroscopy, and fluorescence lifetime imaging to investigate nucleic acid mechanics and cellular processes.
Wilhelmsson actively secures research funding, with current projects including Mechanical Characterisation of Nucleic Acids using Single Molecule Methods (MeCHaNiSM) (2024-2028, EU-funded), Enkelmolykylanalys av RNA-baserade terapier (2023-2026, SSF-funded), and several VR-funded projects on RNA labeling and structure. He has supervised numerous PhD students and postdocs, many of whom appear as co-authors on his publications.
Wilhelmsson founded the FB3 conference series and established the company LanteRNA, demonstrating his commitment to translating basic research into practical applications. His laboratory employs interdisciplinary approaches combining synthetic chemistry, biophysics, and cell biology to develop tools for studying nucleic acids in vitro and in living cells.
