معرفی
Marco Rusnati is a full professor and Head of the Macromolecular Interaction Analysis Unit at the Department of Molecular and Translational Medicine, Brescia University. His research focuses on angiogenic growth factors, viral protein interactions, and biomolecular analysis using surface plasmon resonance. He holds a biology degree from Milan University (1985) and has authored 143 peer-reviewed articles with an h-index of 53.
Research Interests: Core themes include viral entry mechanisms (SARS-CoV-2, HIV, HPV), antiangiogenic drug development targeting FGF/FGFR and Eph/ephrin pathways, and heparan sulfate proteoglycan biology. His lab innovates in plasmonic biosensors, small molecule design, and computational drug discovery.
Recent Advances: Recent work highlights antiviral strategies against SARS-CoV-2 using polysaccharides and heparin mimetics, broad-spectrum antiviral compounds, and BAG3-targeted therapies for pediatric cancers. His 2024 studies on FGF traps and Eph receptor antagonists advance anti-myeloma and anti-angiogenic therapies.
Technical Expertise: Combines surface plasmon resonance (SPR) with molecular dynamics simulations to study protein interactions, drug repositioning pipelines for CFTR disorders, and functionalization of nanoparticles for diagnostic applications.
Laboratory Activities: The Macromolecular Interaction Unit specializes in high-resolution molecular interaction analysis, developing novel tools for drug discovery and virology research. Ongoing projects include exosome functionalization, UV-C protein modification strategies, and thrombospondin-1 signaling in bone metastases.
