Marco Mangone

Marco Mangone is an Associate Professor at Arizona State University (ASU), affiliated with the School of Life Sciences and the Biodesign Virginia G. Piper Center for Personalized Diagnostics. He joined ASU's faculty in August 2011 after completing a postdoctoral fellowship at New York University's Center for Genomics and Systems Biology.

Education:

• Ph.D. in Molecular Biology from Cold Spring Harbor Laboratory (2006)
• Italian Laurea (Dottorato) in Computational Analysis of Single-Nucleotide Polymorphisms from La Sapienza University, Rome (2000)

Research Interests: His work centers on understanding eukaryotic RNA transcription termination and the regulation of mRNA 3'Untranslated Regions (3'UTRs). He uses C. elegans as a model system to investigate mechanisms of alternative polyadenylation (APA), miRNA targeting, and their roles in diseases like cancer, Alzheimer's, and Duchenne muscular dystrophy. His approach integrates high-throughput genomics, bioinformatics, genetics, and systems biology to explore fundamental questions about gene regulation at the post-transcriptional level.

Grants & Service:

• NIH/NIGMS R01 GM118796-01 (2016–2021) PI: 100% funding, focusing on APA and miRNA regulation in C. elegans.
• Biology Graduate Program Director (2019–2023) and member of the Molecular & Cellular Biology Ph.D. Executive Committee (2011–2019).
• ASU Senate representative (2015–2020) and Residency Appeal Committee member (2015–present).

Outreach & Labs: Dr. Mangone’s lab develops tools like the 3'LIFE assay and human 3'UTRome library. His outreach initiatives include K-12 lectures on genomics and public engagement through worm-based experiments. The lab collaborates with institutions like the Biodesign Institute and Texas A&M on translational research projects.

Labs/Teams:

• Mangone Lab at ASU’s Biodesign Institute.
• Co-organizer of the Cold Spring Harbor Asia meeting on RNA Therapeutics (2025).