معرفی
Maoli Duan is an Associate Professor and Senior Consultant at the Karolinska Institutet, affiliated with the Department of Clinical Science, Intervention and Technology under the Ear, Nose and Throat Diseases division. With over 150 peer-reviewed publications, his translational research bridges animal models and clinical applications in otolaryngology.
- Academic Rank: Associate Professor (Karolinska Institutet, 2006)
- Doctoral Degree: Department of Physiology and Pharmacology, Karolinska Institutet (1999)
Research Focus
Dr. Duan's work centers on gene therapy and stem cell treatments for sensorineural hearing loss, with recent breakthroughs in AAV vector delivery for congenital deafness. His 2025 Nature Medicine study demonstrated hearing restoration in patients with OTOF gene mutations through viral gene replacement.
Publication Trends
His 15 most recent articles (2023-2025) span biomedical engineering, clinical otology, and translational neuroscience. Key subfields include inner ear drug delivery, cochlear implants, gene therapy protocols, and viral vector optimization. Notably, his team has pioneered non-invasive approaches to treating Meniere's disease and noise-induced hearing loss.
Collaborative Networks
Dr. Duan collaborates with institutions across Europe, Asia, and North America, with recurring co-authors from Karolinska Institutet, University of Gothenburg, and Shanghai Jiao Tong University. His work appears in Nature Medicine, PNAS, and Advanced Science.
Scientific Context
Dr. Duan's research aligns with global efforts to address genetic hearing disorders through molecular interventions. His team's clinical trials demonstrate that gene therapy can restore near-normal hearing in OTOF mutation carriers without major adverse events, opening new pathways for non-invasive auditory restoration in both pediatric and adult populations.
