معرفی
Mads Lerdrup is an Associate Professor at the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, where he leads research in the Molecular Aging Program. His work focuses on understanding how mammalian organisms handle inbuilt genomic conflicts of interest, particularly during embryonic development.
Education
- Ph.D., University of Copenhagen (2007)
- M.Sc., University of Copenhagen (2002)
Dr. Lerdrup's research centers on the remarkable genomic environment during mammalian fertilization and early embryonic development. His laboratory investigates extensive genomic reprogramming, epigenetic mark rewriting, and retrotransposon activity during these critical stages. He has pioneered the development of single-cell and low-input genome-wide methods to study replication stress in early mammalian embryos and the factors that instruct changes in oocyte and embryo epigenomes. His work has resulted in a comprehensive software suite for genome-wide data analysis (easeq.net).
His recent publications demonstrate significant contributions to understanding transcription-replication collisions, histone modifications, DNA replication in embryos, and mitochondrial dysfunction related to aging. His research spans multiple high-impact journals including Nature Communications, Nature Biotechnology, Science Advances, and Nature Genetics.
Dr. Lerdrup maintains an active research network with collaborations across multiple countries and has developed a side business as founder and owner of the consulting firm genessence (2022-2025).
Research Activities
- Establishment of new single-cell and low-input genome-wide methods
- Identification of causes for replication stress in the early mammalian embryo
- Identification of factors instructing changes in oocyte and embryo epigenomes
