معرفی
M. Mahmood Hussain is a Professor in the Department of Cell Biology at SUNY Downstate Medical Center. His research focuses on molecular mechanisms of intestinal lipoprotein assembly, particularly chylomicron biosynthesis and protein-protein interactions between apolipoprotein B (apoB) and microsomal triglyceride transfer protein (MTP).
Dr. Hussain holds multiple advanced degrees including PhD, MD, MS, and MPH. His laboratory investigates how high plasma lipid and lipoprotein levels contribute to atherosclerosis risk, with the goal of developing new approaches to lower plasma lipid levels. His work has important implications for cardiovascular and neurodegenerative disorders.
His research program is organized around two main areas: the biosynthesis of chylomicrons and protein-protein interactions between apoB and MTP. He has developed cell culture models to study intestinal lipoprotein assembly and has identified specific molecular steps involved in the process. His work on the apoB-MTP interaction has led to the identification of critical binding sites and novel antagonists that inhibit this interaction.
Dr. Hussain's publication record shows a strong focus on lipoprotein assembly mechanisms, chylomicron formation, and related disorders. His recent work has explored the molecular details of lipoprotein assembly stages, protein-lipid interactions, and the role of specific enzymes in lipid metabolism. His research spans biochemistry, molecular biology, and cell biology with applications to cardiovascular disease.
- Irvine H. Page Award, Council on Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, National Center (1998)
- Leonard N. Horowitz Research Award, American Heart Association, Southeastern Pennsylvania Affiliate (1998)
- Established Investigator, American Heart Association, National Center (1999-2002)
- International Journal of Oncology, Oncology Reports, International Journal of Molecular Medicine Award For Outstanding Achievement (2001)
Dr. Hussain has advised numerous students and postdoctoral fellows, including PhD students, MD/PhD students, and research associates. He has served on multiple NIH and American Heart Association grant review committees and has been an active reviewer for major journals in his field. He has also held editorial positions including Managing Editor of Frontiers in Biosciences and Guest Editor for Cardiovascular Drug Reviews.
