معرفی
Luke O'Connor is an Assistant Professor of Biomedical Informatics at Harvard Medical School, affiliated with the Department of Biomedical Informatics. He leads the O'Connor Lab, which focuses on the genetic architecture of common diseases, statistical methods development, and translating genetic associations into biological insight. His work bridges computational and experimental approaches to understand the functional and phenotypic effects of genetic variation.
Education: O'Connor earned his Ph.D. in Bioinformatics and Integrative Genomics (BIG) from Harvard Medical School in 2019. He was a Schmidt Fellow/Principal Investigator at the Broad Institute of MIT and Harvard before joining Harvard Medical School.
Research Interests: His research emphasizes statistical genetics, functional genomics, and the integration of genetic data with phenotypic outcomes. Key areas include analyzing rare and common genetic variants, developing methods for polygenic risk prediction, and studying the impact of genetic perturbations on cellular and disease mechanisms.
Grants: He currently leads an NIH-funded project (R35GM155278) investigating the functional and phenotypic effects of protein-coding genetic variation. This work aims to bridge gaps between genomic data and biological understanding.
Labs/Teams: The O’Connor Lab collaborates with institutions like the Broad Institute and engages in interdisciplinary projects to advance precision medicine and genetic discovery.
