Ludovic Bretin

Ludovic Bretin is a Guest Researcher at the Leiden Institute of Chemistry (LIC) within Leiden University's Faculty of Science. He is affiliated with the department LIC/ES/Metal in Cat. Biom. & Inorg. Mat., focusing on catalysis and biomimetic chemistry. His work integrates inorganic materials and medicinal applications, particularly in developing ruthenium-based phototherapeutic agents for cancer treatment.

Research interests include the design of metallopeptides for targeted drug delivery, photoactivated chemotherapy mechanisms, and oxygen-dependent drug interactions. Notable contributions include cyclic ruthenium-peptide conjugates for brain tumor treatment, published in Journal of the American Chemical Society (2023) and Journal of Medicinal Chemistry (2024). These studies highlight innovations in tumor-targeting prodrugs and enzyme inhibition strategies.

Collaborations involve interdisciplinary teams, such as with Prof. S. Bonnet, addressing challenges in anticancer drug delivery and photodynamic therapy. His research emphasizes translational applications, combining material science and clinical relevance.