معرفی
Luca Jovine is a Professor at Karolinska Institutet's Department of Medicine, Huddinge. His research group focuses on structural biology of fertilization and zona pellucida module proteins. Key areas include egg-sperm interaction mechanisms, urinary tract infection defense proteins (e.g., uromodulin), and kidney disease-related molecules. His work bridges structural insights with clinical applications in infertility, contraception, and disease treatment.
- Affiliations: Karolinska Institutet, Department of Medicine, Huddinge
- Research Themes: Egg-Sperm Interaction, Zona Pellucida Proteins, Structural Biology, Non-Hormonal Contraception, Urinary Tract Infections
His studies utilize advanced techniques like cryo-EM and AlphaFold to resolve protein structures (e.g., ZP3, endoglin, uromodulin) and their roles in health and disease. Awards include the Göran Gustafsson Prize (2012) and Fernström Prize (2011). His lab collaborates internationally and has received grants exceeding SEK 100 million from the Knut and Alice Wallenberg Foundation.
Grants and collaborations highlight translational goals, such as developing non-hormonal contraceptives and understanding kidney stone formation via uromodulin. The lab also explores archaeal proteins' role in gamete fusion evolution and Hedgehog signaling in cancer.
