معرفی
Luca Jovine is a Professor at Karolinska Institutet's Department of Medicine, Huddinge. His research group focuses on structural studies of fertilization and zona pellucida module proteins, exploring molecular mechanisms underlying egg-sperm interaction and their implications for infertility and non-hormonal contraception. His work integrates structural biology techniques like X-ray crystallography and cryo-EM, alongside collaborations with computational methods (e.g., AlphaFold). Jovine has secured significant grants, including SEK 96 million from the Swedish Research Council (2024–2029), and leads projects on egg coat architecture, bacterial defense proteins (uromodulin), and the evolutionary origins of fertilization proteins.
Research highlights include the structural basis of fertilization blockade via antibodies targeting ZP2, the role of ZP2 cleavage in preventing polyspermy, and the discovery of archaeal Fusexins as gamete fusion homologues. His lab also investigates clinically relevant proteins like endoglin in vascular diseases and uromodulin in kidney disorders. Postdoctoral openings are available for candidates with structural/molecular biology expertise. Collaborations span reproductive medicine, infectious disease, and evolutionary biology.
