معرفی
Dr. Louis Luk is a Senior Lecturer at the School of Chemistry, Cardiff University, leading a research group that bridges chemistry and biology to advance protein science and biocatalysis. His work spans medicinal chemistry, antibacterial peptide research, bioactive candidate design, and biotherapeutic manufacturing.
- Current roles: Senior Lecturer (2020-present), Lecturer (2019-2020), Cardiff University Research Fellow (2016-2020)
- Research areas: protein labeling, D-peptide technology, enzyme design, racemic crystallography
Research Focus:
The group develops scalable and precise protein labeling methods via biocatalysis, discovers peptide binders as medicinal chemistry leads, and synthesizes bifunctional ligands for targeted protein degradation. Techniques include peptide synthesis, molecular cloning, enzyme engineering, and structural biology. Trainees gain skills applicable in academia and industry.
Publications (2024-2021):
Recent work explores AEP compartmentalization, genetic code expansion, cyclic enzyme topology, and DHFR dynamics. Studies span racemic crystallography, organocatalysis in protein hosts, and folate modification for targeted delivery.
Grants & Collaborations:
Principal Investigator for BBSRC (2021-2024), Royal Society (2018-2020), Leverhulme Trust (2017-2020), and Wellcome Seed Trust (2016-2018) projects. Collaborations include Cardiff University researchers (Tsai, Jin) and international institutions (University of British Columbia, ETH Zurich).
Teaching & Leadership:
Teaches modules on drug discovery, chemical biology, and supramolecular chemistry. Holds leadership roles in RSC committees and Cardiff School of Chemistry ethics/EDI initiatives.
