معرفی
Lisa Wagar, PhD is an Assistant Professor in the Department of Physiology & Biophysics at the University of California, Irvine School of Medicine. Her research focuses on developing organoid models of human tissues to study infectious diseases and immune responses. She pioneered methods for culturing distal lung organoids to model SARS-CoV-2 infection and has contributed to understanding stem cell heterogeneity in lung tissues. Her work on immune organoids, including tonsil and lymphoma models, advances vaccine design and cancer immunotherapy.
Dr. Wagar's research integrates organoid systems with single-cell analysis to study progenitor cell biology and viral pathogenesis. Key achievements include identifying club cells as novel SARS-CoV-2 infection targets and characterizing dendritic cell subsets in human tissues. Her interdisciplinary approach bridges basic biology, clinical applications, and translational research in regenerative medicine.
Her publications span high-impact journals like Nature and Nature Medicine, with grants from NIH (e.g., R01 HL142549) supporting her work. Ongoing studies explore immune cell heterogeneity, vaccine efficacy modeling, and organoid applications for personalized medicine.
