معرفی
Lisa-Marie Nisbett is an Assistant Professor in the Department of Microbiology at the College of Agriculture and Life Sciences (CALS), Cornell University. She earned her B.S. and M.S. in Biology from Long Island University's LIU Post Campus (2009 and 2012) and a Ph.D. in Biochemistry and Structural Biology from Stony Brook University (2018). Her postdoctoral work as an IRACDA NY-CAPS fellow at Stony Brook University focused on mycobacterial cell envelope biogenesis and lipid export pathways, particularly the role of the lipoprotein LprG in mycomembrane formation.
- Education:
- B.S. in Biology (2009), Long Island University - LIU Post Campus
- M.S. in Biology (2012), Long Island University - LIU Post Campus
- Ph.D. in Biochemistry and Structural Biology (2018), Stony Brook University
The Nisbett Lab investigates the molecular mechanisms driving pathogenesis in nontuberculous mycobacteria (NTM), which are increasingly problematic clinical pathogens causing antibiotic-resistant pulmonary infections. Using Mycobacterium abscessus as a model, her team employs genetic, biochemical, and metabolite quantification approaches to study biofilm formation – a key factor in NTM persistence and treatment resistance. Her work explores how lipid transport systems like LprG contribute to mycomembrane integrity and whether these mechanisms can be targeted for novel anti-infective therapies.
Research trends across her publications reveal a focus on bacterial signaling networks (e.g., c-di-GMP), NO/H-NOX pathways, and heme sensing mechanisms that regulate biofilm formation in diverse species including Shewanella oneidensis, Burkholderia thailandensis, and Mycobacterium smegmatis. These studies span molecular microbiology, structural biology, and chemical biology approaches to understanding microbial pathogenesis.
Contact: lisa-marie.nisbett@cornell.edu | Wing Hall 113, Cornell University, Ithaca, NY 14853
