Lisa Gralinski

Dr. Lisa Gralinski is an Assistant Professor in the Department of Epidemiology at the Gillings School of Global Public Health, University of North Carolina at Chapel Hill. She holds a PhD in Microbiology and Immunology from the University of Michigan (2008) and a BA in Biology from Haverford College (2002). Her research focuses on viral pathogenesis, particularly the interaction between coronaviruses (e.g., SARS-CoV-2) and host immune systems, and the role of genetic variation in disease severity. She leads studies on antiviral and immune-modulatory therapies, leveraging mouse models like the Collaborative Cross.

Her work includes developing vaccines (e.g., MVA-based vaccines) and identifying broadly neutralizing antibodies against betacoronaviruses. She has been recognized with multiple awards, including inclusion in Clarivate's 2022–2024 Highly Cited Researchers Lists. Her research spans SARS-CoV-2 pathogenesis, chronic lung disease modeling, and genetic loci influencing viral outcomes.

• Key Research Themes:
  • Host genetics and respiratory virus susceptibility
  • Coronavirus immune evasion mechanisms
  • Therapeutic target discovery
• Notable Contributions:
  • Mouse-adapted models for SARS-CoV-2 countermeasure testing
  • Identification of multitrait loci regulating sarbecovirus disease
  • Broadly neutralizing antibody development

Dr. Gralinski collaborates widely, including with UNC's Genetics Department and Global Health initiatives. Her research bridges basic science and clinical translation, addressing global health challenges posed by emerging viruses.