Lin Guo

Lin Guo serves as Assistant Professor in the Department of Biochemistry & Molecular Biology at Thomas Jefferson University's College of Life Sciences, where her research program investigates molecular mechanisms of protein phase transitions in neurodegenerative disorders.

Education:

• PhD in Chemistry, University of Pennsylvania, 2011
• BS, Peking University, Beijing, China, 2005

Her laboratory specializes in liquid-liquid phase separation phenomena, examining how aberrant transitions drive pathological aggregate formation in diseases like ALS and FTD. Employing integrated biochemical, molecular, cellular, and biophysical methodologies, her team develops therapeutic strategies targeting stress granule dynamics and protein fibrillization. Current work emphasizes C9orf72-ALS/FTD dipeptide repeats, FUS aggregation pathways, and nuclear import receptor interactions.

Dr. Guo maintains an active research laboratory with dedicated facilities, as evidenced by her institutional lab website. While specific student mentorship details and grant portfolios aren't documented in the source text, her publication record indicates significant contributions to understanding TDP-43 nuclear localization defects and poly(GR)-mediated neurotoxicity mechanisms.