Leslie Sanderson

Leslie Sanderson is an Assistant Professor in the Department of Clinical Genetics at Erasmus MC, where she conducts research on rare genetic neurological disorders. Her work integrates molecular genetics, zebrafish models, and cellular biology to understand disease mechanisms and identify potential therapies.

Her research focuses on neurogenetic conditions, particularly leukodystrophies, microglial dysfunction, lysosomal storage disorders such as mucopolysaccharidosis, and hereditary spastic paraplegias. She investigates the role of genes involved in membrane trafficking (e.g., VPS16, VPS41, AMFR) and microglial regulation (e.g., CSF1R) in neurodegeneration.

The recent articles highlight a strong trend in identifying novel genetic causes of rare diseases and exploring repurposed drug treatments, such as statins. Her studies often involve international collaborations and utilize zebrafish and patient-derived fibroblasts to model disease and test therapeutic interventions.

• No scientific awards mentioned in the provided text.

There is no information available about student advising, grants, or formal mentorship roles in the given text. Her collaborative publications suggest involvement in large research consortia and team-based science, but specific details on grants or leadership roles are not provided.

Leslie Sanderson is part of a research team at Erasmus MC focused on clinical genetics and neurodegenerative diseases, likely working within a laboratory environment that uses zebrafish and cellular models to dissect disease mechanisms. She collaborates closely with senior researchers such as Dr. T.J. van Ham and other international experts in genetics and neurology.