Herma van der Linde

Herma van der Linde is a researcher at Erasmus University Medical Center's Department of Clinical Genetics, leveraging zebrafish models to investigate genetic mechanisms of human diseases with emphasis on neurological, cardiac, and gastrointestinal disorders.

Her research integrates multiple disciplines through:

• Neurogenetics of motor neuron diseases and leukodystrophy
• Molecular pathways in cardiomyocyte adhesion and heart development
• Intestinal morphogenesis and motility disorders
• Therapeutic translation including statin repurposing
• Cellular mechanisms of filamin isoforms and cytoskeletal regulation

Recent publications demonstrate consistent focus on zebrafish-based discovery of disease-causing variants (e.g., AMFR, CSF1R, FLII), with strong translational emphasis on identifying druggable pathways. Her work bridges basic developmental biology with clinical applications across neurology, cardiology, and gastroenterology.

Collaborative networks span international institutions as evidenced by multi-author publications, reflecting integrated approaches to complex genetic disorders through the Clinical Genetics department's research infrastructure.