معرفی
Jennifer L Orthmann-Murphy is an Assistant Professor of Neurology at the University of Pennsylvania's Perelman School of Medicine, where she serves as Co-Director of the Age Span Fellowship in MS/Neuroinflammatory Disorders. She is faculty at the Mahoney Institute for Neurosciences and leads the Orthmann-Murphy Laboratory, which focuses on glial cells in acquired and inherited demyelinating diseases.
Dr. Orthmann-Murphy completed her education at the University of Pennsylvania, earning a B.A. in Biological Basis of Behavior (2001), followed by a Ph.D. in Neuroscience (2007) and an M.D. (2010) through the Combined Degree Program at the Perelman School of Medicine. Her post-graduate training included residency in Neurology at UPenn (2011-2014), followed by postdoctoral fellowship at Johns Hopkins School of Medicine in Neuroscience and Neurology (2014-2018), with additional clinical experience in neurogenetics and leukodystrophy clinics.
Her research focuses on the dynamic role of glial cells in demyelinating diseases, with particular expertise in multiple sclerosis, inherited white matter disorders, and the processes of demyelination and remyelination. The Orthmann-Murphy Laboratory employs advanced techniques including multiphoton imaging to investigate how glial cells contribute to both acquired and inherited myelin disorders, with the goal of identifying novel therapeutic approaches.
Dr. Orthmann-Murphy's work spans basic science, translational research, and clinical applications, with significant contributions to understanding adult leukodystrophies, CSF1R-related disorders, and genetic testing in neurology. Her recent publications demonstrate a strong focus on the intersection of neuroimmunology, neurogenetics, and white matter disorders, with increasing emphasis on clinical guidelines and patient care frameworks for rare neurological conditions.
She has received significant research funding including an R01 grant from the National Institute of Neurological Disorders and Stroke and multiple grants from the National Multiple Sclerosis Society to support her work on microglial and astrocyte contributions to cortical remyelination. She serves on the Scientific Advisory Board of the APBD Research Foundation and has been featured in educational content for organizations like the United Leukodystrophy Foundation.
Dr. Orthmann-Murphy directs the Undiagnosed White Matter Disorders Neurogenetics Clinic at Penn, where she specializes in complex cases that may be misdiagnosed as multiple sclerosis. Her clinical expertise includes Multiple Sclerosis, Neuroimmunology, and Inherited White Matter Disorders, with particular focus on adult polyglucosan body disease and CSF1R-related disorders.
She mentors several trainees including PhD candidates and postdoctoral fellows, and is actively involved in the Gliadelphia research community, which brings together Philadelphia-area researchers studying glial biology. Her work bridges basic neuroscience with clinical neurology to advance understanding and treatment of demyelinating diseases.
