معرفی
Leonardo Sorci serves as an Associate Professor at Universita Politecnica delle Marche (UNIVPM), affiliated with the School of Engineering and the Department of Science and Engineering of Matter, Environment and Urban Planning. His academic appointment is specifically within the Division of Bioinformatics and Biochemistry, where he contributes to teaching and research in biochemical sciences. His office is located at Monte Dago - Via Ranieri 67 - Quota 150, Edificio 5 - stanza 86, with regular office hours on Fridays from 14:00-16:00.
Professor Sorci's research focuses on NAD metabolism and its implications in human disease, particularly examining the biochemical mechanisms of nicotinamide phosphoribosyltransferase (NAMPT) and related enzymes. His work bridges fundamental biochemistry with translational applications in cancer research and inflammatory diseases. He has made significant contributions to understanding how NAD biosynthesis pathways influence tumor resistance mechanisms, particularly in melanoma and non-small cell lung cancer. His laboratory investigates the structural and functional aspects of enzymes involved in NAD metabolism, with special attention to their roles as potential therapeutic targets.
Analysis of Professor Sorci's recent publications reveals a strong thematic focus on NAD metabolism across multiple biological contexts. His work spans bacterial NAD biosynthesis pathways, cancer cell resistance mechanisms, inflammatory signaling through TLR4, and structural studies of key metabolic enzymes. The research demonstrates interdisciplinary integration of biochemical, structural, and pharmacological approaches to develop novel inhibitors targeting specific nodes in NAD metabolic networks. A significant portion of his recent work examines the extracellular roles of NAMPT and NAPRT as cytokine-like mediators in inflammatory processes.
Professor Sorci maintains an active research program with consistent high-impact publications, demonstrating leadership in the field of NAD metabolism research. His work has established important connections between fundamental enzymology and disease mechanisms, particularly in cancer and inflammation. While specific grant information isn't provided in the available materials, his publication record suggests sustained research funding supporting his laboratory's investigations into NAD-related biochemical pathways and their therapeutic implications.
