Ambra Grolla

Ambra Grolla is an Associate Professor at the Department of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale "Amedeo Avogadro". She previously held a Researcher position at the same institution. Her research focuses on Nicotinamide Phosphoribosyltransferase (NAMPT), its role in metabolic pathways, and its implications in cancer, neurodegenerative diseases like Alzheimer's, and inflammatory conditions. Her work integrates drug development, cell signaling, and immunotherapy strategies.

Key research areas include:

• Cancer Biology: Triple-negative breast cancer, ovarian cancer, and mesothelioma targeting.
• Metabolic Pathways: NAMPT-driven metabolism and its role in tumor progression.
• Immunotherapy: eNAMPT's impact on immune evasion and T cell activity.
• Neurodegeneration: Astrocyte dysfunction in Alzheimer's disease.

Recent projects include:

• "Old dog, new tricks": Developing HDAC inhibitors for triple-negative breast cancer.
• Characterizing eNAMPT as a therapeutic target in ovarian cancer and inflammatory bowel diseases.

Her publications (43+ articles) highlight novel inhibitors (e.g., CYP4A11, TN-16 analogs), biomarker studies (e.g., miR-22/GLUT1 axis), and mechanistic insights into calcium signaling and ER-mitochondrial interactions in disease contexts.

Grants and collaborations span Italy (AIRC, Fondazione Cariplo) and include studies on drug design, cancer metabolism, and immunology. Her work contributes to UN Sustainable Development Goals related to health and innovation.