معرفی
Leo James is a Research Professor in Host-Pathogen Biology at the University of Cambridge's Medical Research Council Laboratory of Molecular Biology (MRC-LMB). His lab investigates intracellular immunity, focusing on the evolutionary arms race between hosts and pathogens.
- Discovery of TRIM21, the highest-affinity antibody receptor in mammals
- Development of the TrimAway technique for rapid protein depletion
- Elucidation of HIV-1 capsid dynamics and IP6 regulation
Research spans biophysics to in vivo models, with recent work on HIV-1 capsid stability, tau protein degradation, and TRIM21's role in vaccine-induced immunity. His lab's findings are critical for antiviral therapies and neurodegenerative disease treatments.
Key publications highlight HIV-1 capsid mechanisms, tau immunotherapy, and TRIM21's role in antibody-mediated degradation. Collaborations include international efforts on SARS-CoV-2 and HIV research.
Students and team members include Anna Albecka-Moreau, Aminu Jahun, and others working on pathogen-host interactions and molecular immunity.
