معرفی
Laura Schramm serves as Professor and Associate Dean in the Department of Biological Sciences at St. John's University's College of Liberal Arts and Sciences. Her research program investigates transcriptional dysregulation in oncogenesis with clinical translation potential.
Educational background includes:
- PhD in Molecular and Cellular Pharmacology from SUNY at Stony Brook
- MS in Toxicology from St. John’s University
- BS in Biochemistry from SUNY at Stony Brook
Her research focuses on RNA polymerase III transcription factors (BRF2, BDP1, MAF1) as biomarkers in breast, ovarian, head/neck, and hematologic cancers. She integrates computational bioinformatics with molecular techniques to characterize transcriptional deregulation mechanisms. Current work examines phytochemical modulation (soy isoflavones, green tea EGCG) of RNA pol III activity in chemoprevention contexts.
Analysis of recent publications reveals consistent emphasis on RNA pol III components as clinical biomarkers across multiple cancer types. Her work demonstrates BDP1/BRF2/MAF1 correlations with prognosis in breast, ovarian, and lymphoid malignancies while exploring dietary compound effects on transcriptional regulation.
Scientific recognition includes:
- Clare Boothe Luce Assistant Professorship (2003-2008)
Dr. Schramm mentors graduate students in cancer research while securing funding for biomarker validation studies. Her laboratory bridges computational analysis with wet-bench validation to translate findings into diagnostic applications. Current grants focus on RNA pol III dysregulation mechanisms and phytochemical interventions.
She directs a research laboratory employing integrated omics approaches to identify transcriptional biomarkers. Collaborations with oncologists facilitate clinical correlation studies while student teams investigate molecular mechanisms of phytochemical actions in cancer models.
