معرفی
Dr. Chengfeng Yang is a Professor in the Department of Pathology at the Renaissance School of Medicine, Stony Brook University. His research program focuses on Oncogenic Drivers and Mechanisms of Carcinogenesis, with particular emphasis on RNA dysfunction in cancer development and resistance to therapies.
Dr. Yang received his medical degree from Tongji Medical University, completed his PhD at National University of Singapore, and conducted postdoctoral training at New York University and University of Pennsylvania. This diverse educational background has equipped him with expertise spanning medicine, molecular biology, and toxicology.
His laboratory investigates the role and mechanism of RNA abnormal expression and post-transcriptional modifications in cancer initiation (carcinogenesis), progression (metastasis), and therapeutic resistance. The research is grounded in the recognition that human genome is pervasively transcribed, with a large portion transcribed as non-coding RNAs, especially long non-coding RNAs (lncRNAs). His work demonstrates how environmental carcinogens, particularly metals like hexavalent chromium and arsenic, dysregulate RNA molecules leading to cancer stem cell-like properties and tumorigenesis.
Analysis of Dr. Yang's recent publication record reveals consistent productivity with expanding interdisciplinary connections, particularly between RNA biology, environmental toxicology, and microbiome research. His work bridges molecular biology, toxicology, and oncology, with significant focus on identifying dysfunctional RNA molecules as potential diagnostic markers and therapeutic targets for cancer prevention and treatment.
Dr. Yang actively mentors undergraduate and graduate students in his laboratory, providing research opportunities to study the mechanisms of carcinogenesis. His laboratory serves as a hub for interdisciplinary cancer research at Stony Brook University, collaborating with researchers across multiple departments and institutions.
