معرفی
Lars-Olaf Cardell is a Professor and Senior Physician at Karolinska Institutet's Department of Clinical Science, Intervention and Technology. His work bridges immunology, respiratory medicine, and otorhinolaryngology, with a focus on allergy mechanisms, cancer immunology, and translational clinical research. He leads studies on immune responses in chronic rhinosinusitis, nasal polyps, and head/neck cancers, emphasizing tumor-draining lymph node biology and immunotherapy efficacy.
Cardell’s research integrates clinical trials (e.g., comparing immunotherapy modalities) with mechanistic studies (e.g., neutrophil and regulatory B cell behavior). He collaborates internationally, contributing to EUFOREA guidelines for allergic rhinitis classification and treatment algorithms. His work addresses both basic science (e.g., ILC2 memory) and public health aspects (costs and sustainability of immunotherapy).
Notable contributions include defining phenotypic differences in tumor-associated neutrophils and linking PD-L1 expression to poor oral cancer prognosis. His studies often involve multidisciplinary teams and translational approaches, aiming to improve patient outcomes through biomarker discovery and therapy optimization.
