معرفی
Dr. Lachlan Rash is an Associate Professor at the School of Biomedical Sciences, University of Queensland, with affiliations to the Centre for Innovation in Pain and Health Research (CIPHeR). His research focuses on venom peptides and their interactions with ion channels, particularly acid-sensing ion channels (ASICs) and voltage-gated sodium channels, exploring applications in pain research and neuroprotection.
- Education: BSc (1996) and PhD (2001) from Monash University, specializing in spider venom pharmacology
- Postdoctoral Fellowship with Prof. Michel Lazdunski at the Institute of Molecular and Cellular Pharmacology (France)
Dr. Rash's work spans venom bioprospecting, ion channel characterization, and peptide drug development. His recent publications highlight ASIC inhibitors for multiple sclerosis and myocardial infarction, venom structure-activity studies, and computational modeling of peptide mechanisms.
Key research trends include:
- Development of venom-derived neuroprotective agents like Hi1a and mambalgin-3
- Molecular determinants of ASIC subtype selectivity in pain and ischemia
- Behavioral control of centipede venom composition through evolutionary constraints
He actively supervises PhD students in projects related to venom pharmacology and neuroinflammatory diseases, with funding from the National Multiple Sclerosis Society, NH&MRC, and Multiple Sclerosis Research Australia. His laboratory employs patch-clamp electrophysiology and structural biology techniques to study venom-channel interactions.
