Konstantinos Stellos

Konstantinos Stellos is a Professor and Chairman of the Department of Cardiovascular Research at Heidelberg University's European Center for Angioscience in Mannheim, Germany. His research focuses on the interplay between innate immunity, RNA editing/modification, and vascular inflammation in diseases like atherosclerosis, heart failure, and metabolic disorders. His lab investigates post-transcriptional regulatory mechanisms, particularly ADAR-mediated RNA editing, to identify therapeutic targets and biomarkers for precision medicine. Key areas include the role of RNA modifications in endothelial function, immune cell trafficking, and age-related vascular pathologies.

Publications highlight breakthroughs in understanding RNA editing's impact on cathepsin S expression, ADAR2's role in immune responses, and amyloid-beta's role in neurocardiovascular diseases. Collaborations span immunology, cardiovascular medicine, and RNA biology. His work has led to discoveries in biomarker development (e.g., IP-10 for myocardial recovery) and therapeutic strategies targeting telomerase activation post-infarction.

Lab members include researchers like Dr. Michael Amponsah-Offeh (recipient of the 2024 Young Investigator Award). Ongoing projects explore longevity via vascular signaling and RNA-based therapies. The Stellos Lab's mission is to translate basic discoveries into clinical applications, with a focus on precision medicine for chronic inflammatory and age-related diseases.