Konstantin V Korotkov

Konstantin V Korotkov is an Associate Professor in the Department of Molecular and Cellular Biochemistry at the University of Kentucky, College of Medicine. His research focuses on understanding the molecular mechanisms of bacterial protein secretion systems, particularly the ESX (Type VII) systems in pathogenic bacteria such as Mycobacterium tuberculosis, Staphylococcus aureus, and Bacillus anthracis.

His research interests lie at the intersection of structural biology, biochemistry, and microbial pathogenesis. Using X-ray crystallography, electron microscopy, and biochemical assays, Dr. Korotkov aims to elucidate the architecture and function of the ESX secretion machinery. This knowledge is expected to guide the development of novel antibacterial therapies, especially for tuberculosis. His lab investigates key enzymes and protein complexes involved in bacterial metabolism and virulence, with a strong emphasis on identifying druggable targets.

The recent publications (all from 2019) highlight a consistent focus on structural characterization of bacterial enzymes and secretion system components. These works span topics such as methionine biosynthesis, NAD metabolism, cell wall modifications, and chaperone-mediated protein transport. Collectively, they reflect expertise in structural enzymology and a strategic approach to targeting essential pathways in pathogenic bacteria.

Dr. Korotkov has published in high-impact journals including Nature Chemical Biology, ACS Chemical Biology, Scientific Reports, and Journal of Molecular Biology. While specific awards are not listed, his publication record indicates significant contributions to the field of bacterial pathogenesis and structural microbiology.

He mentors research in a laboratory setting focused on structural and biochemical analysis of bacterial systems. Although specific students are not named, his research program supports graduate and potentially undergraduate research opportunities. Collaborative work is evident from co-authorship with researchers across disciplines, including microbiology, chemical biology, and glycobiology. His lab utilizes shared resources such as protein production facilities and advanced microscopy.

Dr. Korotkov is affiliated with structural and biochemical research facilities at the University of Kentucky, including access to X-ray crystallography and electron microscopy infrastructure. His work is supported by structural biology and infectious disease research networks, and he contributes to the academic mission through research, publication, and training in molecular biochemistry.